About KnowEnG

Knowledge Engine for Genomics

KnowEnG, The Knowledge Engine for Genomics, will transform the way biomedical researchers analyze their genome-wide data by integrating multiple analytical methods derived from the most advanced data mining and machine learning research. Embedded with the breadth of existing knowledge of genes, and an intuitive and professionally designed user interface, the Knowledge Engine platform provides advanced capabilities in data analytics. The KnowEnG environment is deployed in a cloud infrastructure and will be fully available to the research community, as will be the software developed by the Center.

Key Features

Knowledge Network

Gather and integrate existing knowledge bases, document connections between genes and their functions into a single Knowledge Network

Analysis Tools

Develop computational methods for analyzing genome-wide user datasets in the context of pre-existing knowledge

Cloud Computing

Implement analysis methods into scalable software components that can be deployed in a public or private cloud

Visualization Platform

Design and implement a Web-based user interface, based on the HUBZero toolkit, that enables the interactive analysis of user-supplied datasets in a graphics-driven intuitive fashion

Education

Develop tutorials and train on various analysis and sequencing methods available for use with genomic data

Case Study Testing

Test the functionality and usefulness of the KnowEnG environment in three large scale projects in
clinical sciences (pharmacogenomics of breast cancer),
behavioral sciences (identification of gene regulatory modules underlying behavioral patterns) and
drug discovery (genome-based prediction of the capacity of microorganisms to synthesize novel biologically active compounds)