The “KnowEnG” BD2K Center at UIUC (in partnership with Mayo Clinic) is dedicated to the construction of “Knowledge Engine for Genomics” (KnowEnG), a Cloud-based E-science framework for genomics where biomedical scientists will have access to powerful methods of data mining and machine learning to extract important insights out of genomics data. The scientist will go to the KnowEnG portal with their own data sets in the form of spreadsheets and use KnowEnG to analyze those data sets in the light of a massive compendium of community data sets. These data sets, stored in the form of the “Knowledge Network” – a heterogeneous network of genes and their relationships and annotations – will encapsulate prior knowledge that is incorporated into analysis of user data sets.