KnowEnG Knowledge Network

The KnowEnG Knowledge Network (KN) represents community data sets as a massive heterogeneous network, composed primarily of genes (Gene Nodes) and their annotations (Property Nodes) as well as their mutual relationships (Edges). The KN attempts to identify many relevant knowledge bases (Resources), to download their current contents (Datasets) regularly, and to clean and consolidate those disparate resources and construct a unified knowledge graph of multiple relationships (Edge Types) ready for integration with analytic methods.

Detailed information about the Knowledge Network contents can be found here.

More information about mapping gene names and fetching subnetworks can be found here.

Knowledge Network Contents Summary

Version:	KN-20rep-1706
Number of Species:	20
Number of Resources:	14
Number of Datasets:	137
Number of Edge Types:	185
Number of Edges:	476,816,989
Number of Nodes:	583,933
Number of Gene Nodes:	405,439
Number of Property Nodes:	178,493

Detailed information can be found here.

KN Data Resources Summary

	STRING	Edges: 437,711,967
	BLAST: Basic Local Alignment Search Tool	Edges: 20,291,066
	Reactome	Nodes: 45,960, Edges: 1,367,088
	BioGRID: Biological General Repository for Interaction Datasets	Edges: 489,213
	DIP: Database of Interacting Proteins	Edges: 35,926
	IntAct: IntAct Molecular Interaction Database	Edges: 305,246
	HumanNet	Edges: 1,004,509
	Pathway Commons	Nodes: 29,648, Edges: 1,091,999
	Gene Ontology	Nodes: 46,661, Edges: 1,968,720
	Pfam: Pfam Protein Families Database	Nodes: 99,591, Edges: 719,858
	Enrichr	Nodes: 105,874, Edges: 23,314,091
	MSigDB: Molecular Signatures Database	Nodes: 9,542, Edges: 1,460,291

This work is licensed under a Commons Attribution-Non-Commercial-ShareAlike license for academic uses only (https://creativecommons.org/license/by-nc-sa/4.0/, CC BY-NC-SA 4). Where work is the Derivative Works created by KN team from the various databases.

We recommend that the researchers contact owners of the data sources directly to obtain necessary permissions and licenses to download data and/or use it in ways not envisioned in our license. The intent is for the KnowEnG system including KN and Tools to be available for free for academic use only.